Quinolone DNA complexes

Complexes of Quinolone Antibiotics and DNA

Structure of levofloxacin, a prototypical quinolone antibiotic.

Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics.

References

[1] J. Tuma, W. H. Connors, D. H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on Termini of DNA-Duplexes. J. Am. Chem. Soc. 2002, 124, 4236-4246. https://doi.org/10.1021/ja0125117

[2] K. Siegmund, S. Maheshwary, S. Narayanan, W. Connors, M. Riedrich, M. Printz, C. Richert, Molecular details of quinolone-DNA interactions: Solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it. Nucleic Acids Res., 2005, 33, 4838-4848. https://doi.org/10.1093%2Fnar%2Fgki795