Antisense Oligonucleotides
Antisense Oligonucleotides
Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides.
Seminal Papers
[1] Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 280-284. https://doi.org/10.1073/pnas.75.1.280
[2] Stephenson, M. L.; Zamecnik, P. C., Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 285-288. https://doi.org/10.1073%2Fpnas.75.1.285