Antisense Oligonucleotides
Antisense Oligonucleotides
Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides.
Seminal Papers
(a) Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 280-284. https://doi.org/10.1073/pnas.75.1.280
(b) Stephenson, M. L.; Zamecnik, P. C., Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 285-288. https://doi.org/10.1073%2Fpnas.75.1.285