Antisense Oligonucleotides: Difference between revisions
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== | == Antisense Oligonucleotides == | ||
Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides. | Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides. | ||
== | == Seminal Papers == | ||
[1] Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. ''Proc. Natl. Acad. Sci. U.S.A.'' '''1978''', ''75'', 280-284. https://doi.org/10.1073/pnas.75.1.280 | |||
[2] Stephenson, M. L.; Zamecnik, P. C., Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. ''Proc. Natl. Acad. Sci. U.S.A.'' '''1978''', ''75'', 285-288. https://doi.org/10.1073%2Fpnas.75.1.285 | |||
== | == Homepage of the Oligonucleotide Therapeutics Society (OTS) == | ||
https://www.oligotherapeutics.org | https://www.oligotherapeutics.org | ||
Latest revision as of 11:37, 5 August 2024
Antisense Oligonucleotides
Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides.
Seminal Papers
[1] Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 280-284. https://doi.org/10.1073/pnas.75.1.280
[2] Stephenson, M. L.; Zamecnik, P. C., Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 285-288. https://doi.org/10.1073%2Fpnas.75.1.285