Antisense Oligonucleotides: Difference between revisions
(Created page with " '''Antisense Oligonucleotides''' Oligodeoxynucleotides that block translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides. '''Seminal Papers''' (a) Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. ''Proc. Natl. Acad. Sci. U.S.A.'' '''1978''', ''75'', 280-284. (b) Ste...") |
(1) Added links to the cited seminal papers.) |
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Oligodeoxynucleotides that block translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides. | |||
Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides. | |||
'''Seminal Papers''' | '''Seminal Papers''' | ||
(a) Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. ''Proc. Natl. Acad. Sci. U.S.A.'' '''1978''', ''75'', 280-284. | (a) Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. ''Proc. Natl. Acad. Sci. U.S.A.'' '''1978''', ''75'', 280-284. https://doi.org/10.1073/pnas.75.1.280 | ||
(b) Stephenson, M. L.; Zamecnik, P. C., Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. ''Proc. Natl. Acad. Sci. U.S.A.'' '''1978''', ''75'', 285-288. https://doi.org/10.1073%2Fpnas.75.1.285 | |||
'''Homepage of the Oligonucleotide Therapeutics Society (OTS)''' | '''Homepage of the Oligonucleotide Therapeutics Society (OTS)''' | ||
www.oligotherapeutics.org | https://www.oligotherapeutics.org | ||
Revision as of 10:22, 5 August 2024
Antisense Oligonucleotides
Oligodeoxynucleotides that block the translation of specific mRNAs by hybridizing to complementary sequences are called antisense oligonucleotides. They are one class of therapeutic oligonucleotides.
Seminal Papers
(a) Zamecnik, P. C.; Stephenson, M. L., Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 280-284. https://doi.org/10.1073/pnas.75.1.280
(b) Stephenson, M. L.; Zamecnik, P. C., Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 285-288. https://doi.org/10.1073%2Fpnas.75.1.285
Homepage of the Oligonucleotide Therapeutics Society (OTS)