Triplex: Difference between revisions
(Created page with "'''Triple Helices''' or '''Triplexes''' are formed when a third strand binds to a duplex. Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing. Classical Paper Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. ''Biochim. Biophys. Acta.'' '''1957''', ''26'', 457-68. Review Thuong, N.T.; Hélène, C. Sequence-specific recognition and modification of dou...") |
(Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.) |
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Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing. | Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing. | ||
== References == | |||
Classical Paper | === Classical Paper === | ||
[1] Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. ''Biochim. Biophys. Acta.'' '''1957''', ''26'', 457-68. https://doi.org/10.1016/0006-3002(57)90091-4 | |||
=== Review === | |||
[2] Thuong, N.T.; Hélène, C. Sequence-specific recognition and modification of double-helical DNA by oligonucleotides. ''Angew. Chem. Int. Ed. Engl.'' '''1993''', ''32'', 666-690. https://doi.org/10.1002/anie.199306661 | |||
=== Selected Papers on Applications === | |||
[3] C. Kröner, M. Röthlingshöfer, C. Richert, Designed nucleotide binding motifs. ''J. Org. Chem.'' '''2011''', ''76'', 2933-2936. https://doi.org/10.1021/jo2003067 | |||
[4] C. Kröner, M. Thunemann, S. Vollmer, M. Kinzer, R. Feil, C. Richert, Endless: A purine-binding motif that can be expressed in cells. ''Angew. Chem. Int. Ed.'' '''2014''', ''53'', 9198-9202. https://doi.org/10.1002/anie.201403579 | |||
[4] S. Vollmer, C. Richert, DNA triplexes that bind several cofactor molecules. ''Chem. Eur. J.'' '''2015''', ''21'', 18613-18622. https://doi.org/10.1002/chem.201503220 | |||
[5] A. Göckel, C. Richert, Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices. ''Org. Biomol. Chem.'' '''2015''', ''13'', 10303-10309. https://doi.org/10.1039/C5OB01714A | |||
Latest revision as of 12:42, 5 August 2024
Triple Helices or Triplexes are formed when a third strand binds to a duplex.
Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing.
References
Classical Paper
[1] Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. Biochim. Biophys. Acta. 1957, 26, 457-68. https://doi.org/10.1016/0006-3002(57)90091-4
Review
[2] Thuong, N.T.; Hélène, C. Sequence-specific recognition and modification of double-helical DNA by oligonucleotides. Angew. Chem. Int. Ed. Engl. 1993, 32, 666-690. https://doi.org/10.1002/anie.199306661
Selected Papers on Applications
[3] C. Kröner, M. Röthlingshöfer, C. Richert, Designed nucleotide binding motifs. J. Org. Chem. 2011, 76, 2933-2936. https://doi.org/10.1021/jo2003067
[4] C. Kröner, M. Thunemann, S. Vollmer, M. Kinzer, R. Feil, C. Richert, Endless: A purine-binding motif that can be expressed in cells. Angew. Chem. Int. Ed. 2014, 53, 9198-9202. https://doi.org/10.1002/anie.201403579
[4] S. Vollmer, C. Richert, DNA triplexes that bind several cofactor molecules. Chem. Eur. J. 2015, 21, 18613-18622. https://doi.org/10.1002/chem.201503220
[5] A. Göckel, C. Richert, Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices. Org. Biomol. Chem. 2015, 13, 10303-10309. https://doi.org/10.1039/C5OB01714A