Neighbor Exclusion Principle
Neighbor Exclusion Principle
The neighbor exclusion principle of classical intercalation says that between intercalation sites in a duplex one site must remain free. In other words, only every other intercalation site is occupied when classical intercalators bind to duplexes. There are numerous exceptions to this principle.
References
[1] C. Robledo-Luiggi, W.D. Wilson, E. Pares, M. Vera, C.S. Martinez, D. Santiago, Partial intercalation with DNA of peptides containing two aromatic amino acids. Biopolymers 1991, 31, 907-917. https://doi.org/10.1002/bip.360310710
[2] M. Yousuf, I. S. Youn, J. Yun, L. Rasheed, R. Valero, G. Shi, K. S. Kim, Violation of DNA neighbor exclusion principle in RNA recognition. Chem. Sci. 2016, 7, 3581-3588. https://doi.org/10.1039/C5SC03740A (Edge article)