Neighbor Exclusion Principle

Neighbor Exclusion Principle

The neighbor exclusion principle of classical intercalation says that between intercalation sites in a duplex one site must remain free. In other words, only every other intercalation site is occupied when classical intercalators bind to duplexes. There are numerous exceptions to this principle.

References

C. Robledo-Luiggi, W.D. Wilson, E. Pares, M. Vera, C.S. Martinez, D. Santiago, Partial intercalation with DNA of peptides containing two aromatic amino acids. Biopolymers 1991, 31, 907-917.

DOI: 10.1039/C5SC03740A (Edge Article)

M. Yousuf, I. S. Youn, J. Yun, L. Rasheed, R. Valero, G. Shi, K. S. Kim, Violation of DNA neighbor exclusion principle in RNA recognition. Chem. Sci. 2016, 7, 3581-3588.