Aptamers: Difference between revisions
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Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences. | Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences. | ||
'''Selected References''' | '''Selected References''' | ||
[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0 | [1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0 | ||
[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5 | [2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5 | ||
[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801 | [3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801 | ||
[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5. | [4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5. | ||
Revision as of 10:33, 5 August 2024
Aptamers
Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.
Selected References
[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346, 818-822. https://doi.org/10.1038/346818a0
[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. J. Mol. Biol. 1991, 222, 739-761. https://doi.org/10.1016/0022-2836(91)90509-5
[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. Angew. Chem. Int. Ed. Engl. 1997, 36, 480-482. https://doi.org/10.1002/anie.199704801
[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.