Vorbrüggen Base Introduction Reaction: Difference between revisions
(Created page with " '''Vorbrüggen Base Introduction Reaction''' The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, ty...") |
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== Vorbrüggen Base Introduction Reaction == | |||
The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, typically in the form of a trimethylsilyl cation as active species. | The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, typically in the form of a trimethylsilyl cation as active species. | ||
== References == | |||
[1] H. Vorbrüggen, K. Krolikiewicz, B. Bennua, Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts. ''Chem. Ber''. '''1981''', ''114'', 1234-1255. https://doi.org/10.1002/cber.19811140404 | |||
[2] H. Vorbrüggen, B. Bennua, A new simplified nucleoside synthesis. ''Chem. Ber.'' '''1981''', ''114'', 1279-1286. https://doi.org/10.1002/cber.19811140407 | |||
[3] B. Bennua-Skalmowski, K. Krolikiewicz, H. Vorbrüggen, A new simple nucleoside synthesis. ''Tetrahedron Lett.'' '''1995''', ''36'', 7845-7848. https://doi.org/10.1016/0040-4039(95)01667-7 | |||
Latest revision as of 12:52, 5 August 2024
Vorbrüggen Base Introduction Reaction
The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, typically in the form of a trimethylsilyl cation as active species.
References
[1] H. Vorbrüggen, K. Krolikiewicz, B. Bennua, Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts. Chem. Ber. 1981, 114, 1234-1255. https://doi.org/10.1002/cber.19811140404
[2] H. Vorbrüggen, B. Bennua, A new simplified nucleoside synthesis. Chem. Ber. 1981, 114, 1279-1286. https://doi.org/10.1002/cber.19811140407
[3] B. Bennua-Skalmowski, K. Krolikiewicz, H. Vorbrüggen, A new simple nucleoside synthesis. Tetrahedron Lett. 1995, 36, 7845-7848. https://doi.org/10.1016/0040-4039(95)01667-7