Aptamers: Difference between revisions
(Created page with " '''Aptamers''' Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences. '''Selected References''' A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution...") |
(Improved formatting.) |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== Aptamers == | |||
Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences. | |||
== Selected References == | |||
''' | [1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0 | ||
[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5<nowiki/>☃☃ | |||
[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801 | |||
[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5. | |||
S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5. | |||
Latest revision as of 11:37, 5 August 2024
Aptamers
Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.
Selected References
[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346, 818-822. https://doi.org/10.1038/346818a0
[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. J. Mol. Biol. 1991, 222, 739-761. https://doi.org/10.1016/0022-2836(91)90509-5☃☃
[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. Angew. Chem. Int. Ed. Engl. 1997, 36, 480-482. https://doi.org/10.1002/anie.199704801
[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.