Dragos: Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.

2024-08-05T11:52:25Z

Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.

← Older revision		Revision as of 13:52, 5 August 2024
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			== Vorbrüggen Base Introduction Reaction ==

	~~'''~~Vorbrüggen Base Introduction Reaction~~'''~~


	The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, typically in the form of a trimethylsilyl cation as active species.		The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, typically in the form of a trimethylsilyl cation as active species.

			== References ==
			[1] H. Vorbrüggen, K. Krolikiewicz, B. Bennua, Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts. ''Chem. Ber''. '''1981''', ''114'', 1234-1255. https://doi.org/10.1002/cber.19811140404

	~~'''References'''~~		[2] H. Vorbrüggen, B. Bennua, A new simplified nucleoside synthesis. ''Chem. Ber.'' '''1981''', ''114'', 1279-1286. https://doi.org/10.1002/cber.19811140407

	a) H~~. Vorbrüggen, K. Krolikiewicz, B. Bennua, Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts. ''Chem. Ber''. '''1981''', ''114'', 1234-1255.~~

	~~b) H~~. Vorbrüggen, B. Bennua, A new simplified nucleoside synthesis. ''Chem. Ber.'' '''1981''', ''114'', 1279-1286.

	c) B. Bennua-Skalmowski, K. Krolikiewicz, H. Vorbrüggen, A new simple nucleoside synthesis. ''Tetrahedron Lett.'' '''1995''', ''36'', 7845-7848.		[3] B. Bennua-Skalmowski, K. Krolikiewicz, H. Vorbrüggen, A new simple nucleoside synthesis. ''Tetrahedron Lett.'' '''1995''', ''36'', 7845-7848. https://doi.org/10.1016/0040-4039(95)01667-7

Richert: Created page with " '''Vorbrüggen Base Introduction Reaction''' The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, ty..."

2024-06-24T08:14:13Z

Created page with " '''Vorbrüggen Base Introduction Reaction''' The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, ty..."

New page

'''Vorbrüggen Base Introduction Reaction'''

The Vorbrüggen method is perhaps the most important method for linking the base to the sugar in the synthesis of nucleosides. It is named after Helmut Vorbrüggen, an industrial chemist at Schering, Berlin, who worked meticulously on optimizing the reaction conditions, building on a substantial body of work in the earlier literature. The method uses a peracylated glycosyl donor, a silylated base, and a mild Lewis acid, typically in the form of a trimethylsilyl cation as active species.

'''References'''

a) H. Vorbrüggen, K. Krolikiewicz, B. Bennua, Nucleoside synthesis with trimethylsilyl triflate and perchlorate as catalysts. ''Chem. Ber''. '''1981''', ''114'', 1234-1255.

b) H. Vorbrüggen, B. Bennua, A new simplified nucleoside synthesis. ''Chem. Ber.'' '''1981''', ''114'', 1279-1286.

c) B. Bennua-Skalmowski, K. Krolikiewicz, H. Vorbrüggen, A new simple nucleoside synthesis. ''Tetrahedron Lett.'' '''1995''', ''36'', 7845-7848.

Vorbrüggen Base Introduction Reaction - Revision history

Dragos: Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.