https://nucleowiki.uni-frankfurt.de/index.php?action=history&feed=atom&title=Triplex 2026-05-10T18:40:06Z Revision history for this page on the wiki MediaWiki 1.41.1 https://nucleowiki.uni-frankfurt.de/index.php?title=Triplex&diff=72&oldid=prev 2024-08-05T11:42:24Z

<p>Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:42, 5 August 2024</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3">Line 3:</td> <td colspan="2" class="diff-lineno">Line 3:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing.  </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing.  </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Classical Paper</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">=== </ins>Classical Paper <ins style="font-weight: bold; text-decoration: none;">===</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[1] Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. ''Biochim. Biophys. Acta.'' '''1957''', ''26'', 457-68. https://doi.org/10.1016/0006-3002(57)90091-4</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Felsenfeld</del>, <del style="font-weight: bold; text-decoration: none;">G</del>.; <del style="font-weight: bold; text-decoration: none;">Rich</del>, <del style="font-weight: bold; text-decoration: none;">A</del>. <del style="font-weight: bold; text-decoration: none;">Studies on the formation of two</del>- and <del style="font-weight: bold; text-decoration: none;">three</del>-<del style="font-weight: bold; text-decoration: none;">stranded polyribonucleotides</del>. ''<del style="font-weight: bold; text-decoration: none;">Biochim</del>. <del style="font-weight: bold; text-decoration: none;">Biophys</del>. <del style="font-weight: bold; text-decoration: none;">Acta</del>.'' '''<del style="font-weight: bold; text-decoration: none;">1957</del>''', ''<del style="font-weight: bold; text-decoration: none;">26</del>'', <del style="font-weight: bold; text-decoration: none;">457</del>-<del style="font-weight: bold; text-decoration: none;">68</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">=== Review ===</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[2] Thuong</ins>, <ins style="font-weight: bold; text-decoration: none;">N.T</ins>.; <ins style="font-weight: bold; text-decoration: none;">Hélène</ins>, <ins style="font-weight: bold; text-decoration: none;">C</ins>. <ins style="font-weight: bold; text-decoration: none;">Sequence</ins>-<ins style="font-weight: bold; text-decoration: none;">specific recognition </ins>and <ins style="font-weight: bold; text-decoration: none;">modification of double</ins>-<ins style="font-weight: bold; text-decoration: none;">helical DNA by oligonucleotides</ins>. ''<ins style="font-weight: bold; text-decoration: none;">Angew. Chem. Int</ins>. <ins style="font-weight: bold; text-decoration: none;">Ed</ins>. <ins style="font-weight: bold; text-decoration: none;">Engl</ins>.'' '''<ins style="font-weight: bold; text-decoration: none;">1993</ins>''', ''<ins style="font-weight: bold; text-decoration: none;">32</ins>'', <ins style="font-weight: bold; text-decoration: none;">666</ins>-<ins style="font-weight: bold; text-decoration: none;">690. https://doi.org/10.1002/anie</ins>.<ins style="font-weight: bold; text-decoration: none;">199306661</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">=== Selected Papers on Applications ===</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[3] C. Kröner, M. Röthlingshöfer, C. Richert, Designed nucleotide binding motifs. ''J. Org. Chem.'' '''2011''', ''76'', 2933-2936. https://doi.org/10.1021/jo2003067</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Review</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[4] C. Kröner, M. Thunemann, S. Vollmer, M. Kinzer, R. Feil, C. Richert, Endless: A purine-binding motif that can be expressed in cells.  ''Angew. Chem. Int. Ed.'' '''2014''', ''53'', 9198-9202. https://doi.org/10.1002/anie.201403579</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Thuong, N</del>.<del style="font-weight: bold; text-decoration: none;">T.; Hélène</del>, C. <del style="font-weight: bold; text-decoration: none;">Sequence-specific recognition and modification of double-helical </del>DNA <del style="font-weight: bold; text-decoration: none;">by oligonucleotides</del>. ''<del style="font-weight: bold; text-decoration: none;">Angew. </del>Chem. <del style="font-weight: bold; text-decoration: none;">Int</del>. <del style="font-weight: bold; text-decoration: none;">Ed. Engl</del>.'' '''<del style="font-weight: bold; text-decoration: none;">1993</del>''', ''<del style="font-weight: bold; text-decoration: none;">32</del>'', <del style="font-weight: bold; text-decoration: none;">666</del>-<del style="font-weight: bold; text-decoration: none;">690</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[4] S</ins>. <ins style="font-weight: bold; text-decoration: none;">Vollmer</ins>, C. <ins style="font-weight: bold; text-decoration: none;">Richert, </ins>DNA <ins style="font-weight: bold; text-decoration: none;">triplexes that bind several cofactor molecules</ins>. ''Chem. <ins style="font-weight: bold; text-decoration: none;">Eur</ins>. <ins style="font-weight: bold; text-decoration: none;">J</ins>.'' '''<ins style="font-weight: bold; text-decoration: none;">2015</ins>''', ''<ins style="font-weight: bold; text-decoration: none;">21</ins>'', <ins style="font-weight: bold; text-decoration: none;">18613</ins>-<ins style="font-weight: bold; text-decoration: none;">18622. https://doi.org/10.1002/chem.201503220 </ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[5] </ins>A. Göckel, C. Richert, Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices. ''Org. Biomol. Chem.'' '''2015''', ''13'', 10303-10309. <ins style="font-weight: bold; text-decoration: none;">https://doi.org/10.1039/C5OB01714A</ins></div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Selected Papers on Applications</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">1.  C. Kröner, M. Röthlingshöfer, C. Richert, Designed nucleotide binding motifs. ''J. Org. Chem.'' '''2011''', ''76'', 2933-2936.</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">2.  C. Kröner, M. Thunemann, S. Vollmer, M. Kinzer, R. Feil, C. Richert, Endless: A purine-binding motif that can be expressed in cells.  ''Angew. Chem. Int. Ed.'' '''2014''', ''53'', 9198-9202.</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">3.  S. Vollmer, C. Richert, DNA triplexes that bind several cofactor molecules. ''Chem. Eur. J.'' '''2015''', ''21'', 18613-18622. </del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">4.  </del>A. Göckel, C. Richert, Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices. ''Org. Biomol. Chem.'' '''2015''', ''13'', 10303-10309.</div></td><td colspan="2" class="diff-side-added"></td></tr> </table>

Dragos https://nucleowiki.uni-frankfurt.de/index.php?title=Triplex&diff=16&oldid=prev 2024-06-16T12:57:07Z

<p>Created page with &quot;&#039;&#039;&#039;Triple Helices&#039;&#039;&#039; or &#039;&#039;&#039;Triplexes&#039;&#039;&#039; are formed when a third strand binds to a duplex. Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing. Classical Paper Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. &#039;&#039;Biochim. Biophys. Acta.&#039;&#039; &#039;&#039;&#039;1957&#039;&#039;&#039;, &#039;&#039;26&#039;&#039;, 457-68. Review Thuong, N.T.; Hélène, C. Sequence-specific recognition and modification of dou...&quot;</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Triple Helices&#039;&#039;&#039; or &#039;&#039;&#039;Triplexes&#039;&#039;&#039; are formed when a third strand binds to a duplex. <br /> <br /> Triplex formation is known for DNA and RNA. The third strand may bind via Hoogsteen or reverse Hoogsteen base pairing. <br /> <br /> <br /> Classical Paper<br /> <br /> Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. &#039;&#039;Biochim. Biophys. Acta.&#039;&#039; &#039;&#039;&#039;1957&#039;&#039;&#039;, &#039;&#039;26&#039;&#039;, 457-68.<br /> <br /> <br /> Review<br /> <br /> Thuong, N.T.; Hélène, C. Sequence-specific recognition and modification of double-helical DNA by oligonucleotides. &#039;&#039;Angew. Chem. Int. Ed. Engl.&#039;&#039; &#039;&#039;&#039;1993&#039;&#039;&#039;, &#039;&#039;32&#039;&#039;, 666-690<br /> <br /> <br /> Selected Papers on Applications<br /> <br /> 1.  C. Kröner, M. Röthlingshöfer, C. Richert, Designed nucleotide binding motifs. &#039;&#039;J. Org. Chem.&#039;&#039; &#039;&#039;&#039;2011&#039;&#039;&#039;, &#039;&#039;76&#039;&#039;, 2933-2936.<br /> <br /> 2.  C. Kröner, M. Thunemann, S. Vollmer, M. Kinzer, R. Feil, C. Richert, Endless: A purine-binding motif that can be expressed in cells.  &#039;&#039;Angew. Chem. Int. Ed.&#039;&#039; &#039;&#039;&#039;2014&#039;&#039;&#039;, &#039;&#039;53&#039;&#039;, 9198-9202.<br /> <br /> 3.  S. Vollmer, C. Richert, DNA triplexes that bind several cofactor molecules. &#039;&#039;Chem. Eur. J.&#039;&#039; &#039;&#039;&#039;2015&#039;&#039;&#039;, &#039;&#039;21&#039;&#039;, 18613-18622. <br /> <br /> 4.  A. Göckel, C. Richert, Synthesis of an oligonucleotide with a nicotinamide mononucleotide residue and its molecular recognition in DNA helices. &#039;&#039;Org. Biomol. Chem.&#039;&#039; &#039;&#039;&#039;2015&#039;&#039;&#039;, &#039;&#039;13&#039;&#039;, 10303-10309.</div>

Richert