Quinolone DNA complexes - Revision history

Dragos: Added an image of the structure of levofloxacin.

2024-09-03T13:17:28Z

Added an image of the structure of levofloxacin.

← Older revision		Revision as of 15:17, 3 September 2024
Line 1:		Line 1:
	== Complexes of Quinolone Antibiotics and DNA ==		== Complexes of Quinolone Antibiotics and DNA ==
	Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics.
			[[File:Levofloxacin structure.png\|right\|thumb\|Structure of levofloxacin, a prototypical quinolone antibiotic.]]Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics.<br><br><br><br><br><br><br>

	== References ==		== References ==

Dragos: Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.

2024-08-05T11:31:30Z

Cleaned up the page formatting, redid the numbering of the references and added links to the cited papers.

← Older revision		Revision as of 13:31, 5 August 2024
Line 1:		Line 1:
			== Complexes of Quinolone Antibiotics and DNA ==

	~~'''~~Complexes of Quinolone Antibiotics and DNA~~'''~~


	Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics.		Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics.

			== References ==
			[1] J. Tuma, W. H. Connors, D. H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on Termini of DNA-Duplexes. ''J. Am. Chem. Soc.'' '''2002''', ''124,'' 4236-4246. https://doi.org/10.1021/ja0125117

	~~'''References'''~~		[2] K. Siegmund, S. Maheshwary, S. Narayanan, W. Connors, M. Riedrich, M. Printz, C. Richert, Molecular details of quinolone-DNA interactions: Solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it. ''Nucleic Acids Res.'', '''2005''', ''33'', 4838-4848. https://doi.org/10.1093%2Fnar%2Fgki795

	~~a) J. Tuma, W. H. Connors, D. H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on Termini of DNA-Duplexes. ''J. Am. Chem. Soc.'' '''2002''', ''124,'' 4236-4246.~~

	b) K. Siegmund, S. Maheshwary, S. Narayanan, W. Connors, M. Riedrich, M. Printz, C. Richert, Molecular details of quinolone-DNA interactions: Solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it. ''Nucleic Acids Res.'', '''2005''', ''33'', 4838-4848.

Richert: Created page with " '''Complexes of Quinolone Antibiotics and DNA''' Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics. '''References''' a) J. Tuma, W. H. Connors, D. H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on..."

2024-06-23T06:10:45Z

Created page with " '''Complexes of Quinolone Antibiotics and DNA''' Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics. '''References''' a) J. Tuma, W. H. Connors, D. H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on..."

New page

'''Complexes of Quinolone Antibiotics and DNA'''

Quinolone antibiotics are widely used in the clinic. They inhibit the re-sealing of the DNA after cleavage by a gyrase, thus turning a topoisomerase into a nuclease. Three-dimensional structures of covalent quinolone-DNA complexes have been elucidated by NMR and restrained molecular dynamics.

'''References'''

a) J. Tuma, W. H. Connors, D. H. Stitelman, C. Richert, On the Effect of Covalently Appended Quinolones on Termini of DNA-Duplexes. ''J. Am. Chem. Soc.'' '''2002''', ''124,'' 4236-4246.

b) K. Siegmund, S. Maheshwary, S. Narayanan, W. Connors, M. Riedrich, M. Printz, C. Richert, Molecular details of quinolone-DNA interactions: Solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it. ''Nucleic Acids Res.'', '''2005''', ''33'', 4838-4848.