Aptamers - Revision history

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	== ~~'''~~Aptamers~~'''~~ ==		== Aptamers ==

	Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.		Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.

	== ~~'''~~Selected References~~'''~~ ==		== Selected References ==

	[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0		[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0

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			== '''Aptamers''' ==

			Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.
	~~'''Aptamers'''~~
			== '''Selected References''' ==

	Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.

	'''Selected References'''

	[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0		[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0

			[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5<nowiki/>☃☃

	[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5


	[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801		[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801

	[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.		[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.

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	Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.		Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.



	'''Selected References'''		'''Selected References'''



	[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0		[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0




	[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5		[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5




	[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801		[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801



	[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.		[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.

Dragos: Numbered the references and added links to references 1, 2 and 3

2024-08-05T09:32:42Z

Numbered the references and added links to references 1, 2 and 3

← Older revision		Revision as of 11:32, 5 August 2024
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	~~A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822.~~

			[1] A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. https://doi.org/10.1038/346818a0

	~~D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761.~~


	~~M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482.~~

			[2] D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761. https://doi.org/10.1016/0022-2836(91)90509-5

	S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.


			[3] M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482. https://doi.org/10.1002/anie.199704801



			[4] S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.

Richert: Created page with " '''Aptamers''' Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences. '''Selected References''' A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution..."

2024-07-30T08:11:30Z

Created page with " '''Aptamers''' Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences. '''Selected References''' A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822. D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution..."

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'''Aptamers'''

Aptamers are single-stranded RNA or DNA molecules that can fold and bind target structures with high affinity and a specificity comparable to that of antibodies. They are identified by selection from libraries of sequences.

'''Selected References'''

A. D. Ellington, J. W. Szostak, In vitro selection of RNA molecules that bind specific ligands. ''Nature'' '''1990''', ''346'', 818-822.

D. Irvine, C. Tuerk, L. Gold, Selexion - Systematic evolution of ligands by exponential enrichment with integrated optimization by nonlinear-analysis. ''J. Mol. Biol.'' '''1991''', ''222'', 739-761.

M. Egli, In vitro selected receptors rationalized: the first 3D structures of RNA aptamer/substrate complexes. ''Angew. Chem. Int. Ed. Engl.'' '''1997''', ''36'', 480-482.

S. Müller (ed.), Nucleic acids from A to Z - A concise encyclopedia. Wiley-VCH, Weinheim: 2008, ISBN: 978-3-527-31211-5.